David W Ray Selected Research

N- cyano- N'- (2- ((8- (2,6- difluorophenyl)- 4- (4- fluoro- 2- methylphenyl)- 7- oxo- 7,8- dihydropyrido(2,3- d)pyrimidin- 2- yl)amino)ethyl)guanidine

2/2009

Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504).

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David W Ray Research Topics

Disease

13	Inflammation (Inflammations) 01/2022 - 10/2008
8	Neoplasms (Cancer) 01/2022 - 05/2006
5	Asthma (Bronchial Asthma) 12/2020 - 01/2014
5	Rheumatoid Arthritis 01/2018 - 08/2009
4	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2018 - 09/2008
3	Arthritis (Polyarthritis) 01/2022 - 11/2016
3	Infections 12/2021 - 07/2012
3	Weight Gain 01/2020 - 10/2008
3	Diabetes Mellitus 01/2016 - 10/2008
3	Lung Diseases (Lung Disease) 01/2016 - 05/2012
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2016
2	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2022 - 01/2019
2	Rheumatic Diseases (Rheumatism) 01/2020 - 01/2016
2	Metabolic Diseases (Metabolic Disease) 10/2018 - 05/2006
2	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2018 - 01/2016
2	Osteoporosis 01/2016 - 10/2008
2	Pneumonia (Pneumonitis) 03/2014 - 05/2012
2	Hypoxia (Hypoxemia) 09/2012 - 08/2009
2	Cortisone reductase deficiency 10/2008 - 08/2003
1	Hypothyroidism 11/2022
1	Hyperthyroidism 11/2022
1	Disease Progression 01/2022
1	Disorders of Excessive Somnolence (Hypersomnia) 01/2022
1	Leukemia 01/2022
1	Liver Diseases (Liver Disease) 12/2021
1	Chronic Hepatitis B 12/2021
1	Hypersensitivity (Allergy) 12/2020
1	Pneumococcal Pneumonia 01/2020
1	Body Weight (Weight, Body) 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2020
1	Sleep Deprivation 01/2020
1	Primary Graft Dysfunction 01/2019
1	Experimental Arthritis 01/2019
1	Carcinogenesis 01/2018
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 03/2016
1	Lung Neoplasms (Lung Cancer) 01/2016
1	Familial Testotoxicosis 11/2015
1	Hypertension (High Blood Pressure) 11/2015
1	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 11/2015
1	Obesity 01/2015
1	Weight Loss (Weight Reduction) 01/2015
1	Hypercholesterolemia 11/2014
1	Neoplasm Metastasis (Metastasis) 03/2014

Drug/Important Bio-Agent (IBA)

14	GlucocorticoidsIBA 01/2020 - 05/2006
8	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2022 - 10/2008
5	CytokinesIBA 01/2022 - 09/2004
4	Proteins (Proteins, Gene)FDA Link 12/2020 - 02/2009
4	CLOCK ProteinsIBA 12/2020 - 11/2016
4	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2018 - 08/2003
3	Pharmaceutical PreparationsIBA 01/2022 - 10/2018
3	Oxygen (Dioxygen)IBA 01/2020 - 08/2009
3	Biomarkers (Surrogate Marker)IBA 10/2019 - 10/2008
3	Dexamethasone (Maxidex)FDA LinkGeneric 01/2019 - 02/2009
3	AndrogensIBA 11/2015 - 08/2003
3	Adrenocorticotropic Hormone (ACTH)FDA Link 03/2010 - 08/2003
2	CeramidesIBA 01/2022 - 01/2019
2	CollagenIBA 01/2019 - 11/2016
2	ChemokinesIBA 01/2019 - 02/2009
2	SteroidsIBA 11/2015 - 10/2008
2	ChromatinIBA 03/2014 - 05/2006
2	p38 Mitogen-Activated Protein KinasesIBA 05/2012 - 02/2009
2	Macrophage Migration-Inhibitory FactorsIBA 08/2009 - 09/2004
2	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 10/2008 - 08/2003
2	Cortisone FDA Link 10/2008 - 08/2003
2	galactose-6-phosphate dehydrogenaseIBA 10/2008 - 08/2003
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2008 - 02/2003
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 11/2022
1	Thyroxine (Levothyroxine)FDA LinkGeneric 11/2022
1	Insulin (Novolin)FDA Link 01/2022
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2022
1	Histone MethyltransferasesIBA 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	LipidsIBA 01/2022
1	Circular DNAIBA 12/2021
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 12/2020
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2020
1	Carbon DioxideIBA 01/2020
1	GasesIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2019
1	Prostaglandins DIBA 01/2019
1	ProteomeIBA 01/2019
1	AntibodiesIBA 01/2019
1	Biological ProductsIBA 01/2019
1	SmokeIBA 01/2018
1	CryptochromesIBA 11/2016
1	Vitamin D FDA LinkGeneric 03/2016
1	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA 11/2015
1	AdiponectinIBA 01/2015
1	C-Reactive ProteinIBA 01/2015
1	AdipokinesIBA 01/2015
1	MethyltransferasesIBA 03/2014
1	Indicators and Reagents (Reagents)IBA 01/2014
1	AdrenomedullinIBA 09/2013

Therapy/Procedure

13	Therapeutics 01/2022 - 10/2008
2	Drug Therapy (Chemotherapy) 01/2016 - 10/2008
1	Lung Transplantation 01/2019
1	Transplantation 01/2019
1	Bariatric Surgery 01/2015